Fisker, the world?s first environmentally-responsible luxury car made its official Middle East appearance last night as Trading Enterprises and Fisker Automotive leadership unveiled the award-winning Karma sedan in front of global and regional media at Al Badia Golf Club, Dubai Festival City.
Senior management from Al-Futtaim and Fisker Automotive pulled the wraps off the world?s first high performance electric luxury vehicle, making the privately held Dubai-based business group exclusive partner in the GCC and MENA regions.
The launch was attended by Henrik Fisker, Co-Founder and Executive Chairman at Fisker Automotive, Barny Koehler, Co-Founder and CEO of Europe and Middle East, Fisker Automotive, Len Hunt, President ? Automotive, Al-Futtaim Group, Colin Cordery, Managing Director, Trading Enterprises and other senior management from Al-Futtaim.
Trading Enterprises will distribute Fisker automobiles exclusively in the UAE, Saudi Arabia, Qatar, Kuwait, Oman, Bahrain, Egypt and the Levant. The region?s first Fisker showroom will open in Dubai Festival City?s automotive park before the end of the year. Depending on the chosen interior trims, accessories and paint combinations, the Fisker Karma will retail in the UAE for between AED500,000 and AED600,000.
Colin Cordery, Managing Director, Trading Enterprises said: ?We are familiar with first-class automotive brands and understand the need to offer premium customers a technologically advanced vehicle that respects the environment.
?Fisker offers an environmental alternative to traditional luxury vehicles and we are well placed and proud to partner with Fisker and support their vision of delivering uncompromised, responsible luxury to this part of the world. Al-Futtaim has built strength and credibility in delivering great customer experience and this latest partnership with Fisker automobiles further reiterates our position as the region?s number one dealer of the finest automotive brands.?
Henrik Fisker, Co-Founder and Executive Chairman at Fisker Automotive said: ?Today is a proud moment for the Fisker brand as it is the start of our journey in the Middle East. We could not have found a better business house than Al-Futtaim Group to partner us. Al-Futtaim is one of the strongest players in the automotive segment with proven capabilities in customer engagement, high standards of after-sales service, network of showrooms and parts distribution centers. We are honored to have a partner with such strong legacy.?
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ESA start-up company wins GMES Masters awardPublic release date: 26-Oct-2012 [ | E-mail | Share ]
Contact: Robert Meisner robert.meisner@esa.int European Space Agency
The one-man Dutch business BlackShore has won the top prize in the European Earth-monitoring competition. The winning project, Cerberus, exploits social media to advance Earth observation applications.
In its second year, the Global Monitoring for Environment and Security (GMES) Masters competition received more than 100 innovative business proposals from 20 European countries.
The competition fosters creative product development and entrepreneurship in Europe in the GMES service fields: land, ocean, air quality, climate change and emergency response.
The GMES Masters was created by ESA, the Bavarian Ministry of Economic Affairs, the DLR German Aerospace Center and T-Systems, and is supported by the European Commission.
This year, two additional German industry leaders Astrium GEO-Information Services and European Space Imaging GmbH joined the competition as partners.
The 2012 winners were announced on 25 October at an event in Munich, Germany organised by Anwendungszentrum Oberpfaffenhofen (AZO) GmbH.
Volker Liebig, Director of ESA's Earth Observation Programmes, unveiled BlackShore's project Cerberus as the overall winner the GMES Master 2012 endowed with 20 000.
The project, which also won the European Space Imaging High-Res Challenge, is presented as a 'serious game' that involves participants in the creation of digital maps based on GMES data.
Cerberus users can mark where they see, for example, cracks in ice, damaged power cables or areas of drought on satellite images. This input is then translated into map layers to be used, after verification, by governments or other interested parties.
BlackShore is a Dutch start-up company hosted since 2011 at the ESA Business Incubation Centre Noordwijk, part of the Agency's Technology Transfer Programme.
Josef Aschbacher, Head of the ESA GMES Space Office, presented the award for the ESA App Challenge to Dr Harald Skinnemoen and his team from the Norwegian company AnsuR Technologies AS.
Their crowdsourcing app ASIGN provides in-situ visual GMES validation and helps to organise professional field teams for crisis management.
During last year's flooding in Thailand, the ASIGN mobile app demonstrated its usefulness by merging near-realtime information from space and the ground to help those struck by the disaster.
Meanwhile, an offshore oil spill and gas flare monitoring service based on upcoming Sentinel-1 and -2 data, called MOSP-RIOS, was chosen as the winner of the GMES Master's Ideas Challenge. The proposed service was submitted by Daniele Di Erasmo and his team at Serco S.p.A. (Italy).
Taking home the prize of the DLR Environmental Challenge was Steve Lee of Scotland's Stevenson Astrosat Ltd.
The company's thermal and carbon efficiency reporting tool ThermCERT is designed to use space-derived data to increase the quality of thermal output measurements.
Dr Tim McCarthy and his team from the Irish company iGeotec Technologies Ltd won the prize in the T-Systems Cloud Computing Challenge for WAMSAPs Wide-Area Monitoring using Spaceborne and Airborne Platforms.
This novel approach facilitates continuous monitoring of man-made and natural environments in a more timely and comprehensive manner.
Finally, BALIST, submitted by Dr Virginie Lafon and her team from the French Technology Transfer Unit GEO-Transfert, was chosen as the winning submission in the Astrium Radar Challenge.
This nearshore bathymetry service maps coastal water depths using data from the Sentinel-1 and -2 missions, which will be launched from 2013 onwards.
The GMES Masters prize pool has a total value of 335 000 both in cash and in kind, the latter mainly in the form of satellite data or the chance to enter the incubation programme at one of Europe's seven ESA Business Incubation Centres.
The European Commission has contributed satellite data packages worth 100 000 to this year's GMES Masters.
The impressive participation and the quality of the submitted ideas in the competition's first two years have demonstrated that innovative GMES applications possess great economic potential, especially for small- and medium-enterprises and start-up companies.
The aim of the GMES programme is to provide easily accessible information to improve the management of the environment, understand and mitigate the effects of climate change and ensure civil security.
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
ESA start-up company wins GMES Masters awardPublic release date: 26-Oct-2012 [ | E-mail | Share ]
Contact: Robert Meisner robert.meisner@esa.int European Space Agency
The one-man Dutch business BlackShore has won the top prize in the European Earth-monitoring competition. The winning project, Cerberus, exploits social media to advance Earth observation applications.
In its second year, the Global Monitoring for Environment and Security (GMES) Masters competition received more than 100 innovative business proposals from 20 European countries.
The competition fosters creative product development and entrepreneurship in Europe in the GMES service fields: land, ocean, air quality, climate change and emergency response.
The GMES Masters was created by ESA, the Bavarian Ministry of Economic Affairs, the DLR German Aerospace Center and T-Systems, and is supported by the European Commission.
This year, two additional German industry leaders Astrium GEO-Information Services and European Space Imaging GmbH joined the competition as partners.
The 2012 winners were announced on 25 October at an event in Munich, Germany organised by Anwendungszentrum Oberpfaffenhofen (AZO) GmbH.
Volker Liebig, Director of ESA's Earth Observation Programmes, unveiled BlackShore's project Cerberus as the overall winner the GMES Master 2012 endowed with 20 000.
The project, which also won the European Space Imaging High-Res Challenge, is presented as a 'serious game' that involves participants in the creation of digital maps based on GMES data.
Cerberus users can mark where they see, for example, cracks in ice, damaged power cables or areas of drought on satellite images. This input is then translated into map layers to be used, after verification, by governments or other interested parties.
BlackShore is a Dutch start-up company hosted since 2011 at the ESA Business Incubation Centre Noordwijk, part of the Agency's Technology Transfer Programme.
Josef Aschbacher, Head of the ESA GMES Space Office, presented the award for the ESA App Challenge to Dr Harald Skinnemoen and his team from the Norwegian company AnsuR Technologies AS.
Their crowdsourcing app ASIGN provides in-situ visual GMES validation and helps to organise professional field teams for crisis management.
During last year's flooding in Thailand, the ASIGN mobile app demonstrated its usefulness by merging near-realtime information from space and the ground to help those struck by the disaster.
Meanwhile, an offshore oil spill and gas flare monitoring service based on upcoming Sentinel-1 and -2 data, called MOSP-RIOS, was chosen as the winner of the GMES Master's Ideas Challenge. The proposed service was submitted by Daniele Di Erasmo and his team at Serco S.p.A. (Italy).
Taking home the prize of the DLR Environmental Challenge was Steve Lee of Scotland's Stevenson Astrosat Ltd.
The company's thermal and carbon efficiency reporting tool ThermCERT is designed to use space-derived data to increase the quality of thermal output measurements.
Dr Tim McCarthy and his team from the Irish company iGeotec Technologies Ltd won the prize in the T-Systems Cloud Computing Challenge for WAMSAPs Wide-Area Monitoring using Spaceborne and Airborne Platforms.
This novel approach facilitates continuous monitoring of man-made and natural environments in a more timely and comprehensive manner.
Finally, BALIST, submitted by Dr Virginie Lafon and her team from the French Technology Transfer Unit GEO-Transfert, was chosen as the winning submission in the Astrium Radar Challenge.
This nearshore bathymetry service maps coastal water depths using data from the Sentinel-1 and -2 missions, which will be launched from 2013 onwards.
The GMES Masters prize pool has a total value of 335 000 both in cash and in kind, the latter mainly in the form of satellite data or the chance to enter the incubation programme at one of Europe's seven ESA Business Incubation Centres.
The European Commission has contributed satellite data packages worth 100 000 to this year's GMES Masters.
The impressive participation and the quality of the submitted ideas in the competition's first two years have demonstrated that innovative GMES applications possess great economic potential, especially for small- and medium-enterprises and start-up companies.
The aim of the GMES programme is to provide easily accessible information to improve the management of the environment, understand and mitigate the effects of climate change and ensure civil security.
###
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
The biggest shift in brand marketing is not about time, money or budgets?it?s about ownership. Now more than ever, your audience plays a role in defining your brand. You control your brand?s message, yes, but don?t believe for one second that consumers aren?t doing a little ?messaging? of their own. They?re helping to shape your brand, and they?ll have that conversation with or without you. In case you haven?t been formally introduced, welcome to the Land of Social Media.
I was given a press pass for the Pivot Conference hosted by Brian Solis in New York City last week. The lineup of attendees was the Who?s Who of brands including Coca Cola, Hilton, Twitter, Huffington Post, Citibank, Facebook, Bravo, MTV and many more. Topics ranged from becoming a social business to big data to gamification.
But it wasn?t until a lunch panel presentation with Todd Wilms, Sr. Director of Social Media for SAP, when good friend and audience member, Charlie Oliver, asked the question that, to me, was the real question at the conference:
Who owns the brand?the brand itself or the consumer?
She took it a step further and asked, ?What makes one person who buys a product or service any more important than the millions of dollars spent by the brand? By spending millions on brand marketing, does that mean you own your own brand message??
Marketers have differing opinions about this, but I like what founder of Amazon Jeff Bezos, says: ?Your brand is what people say about you when you?re not in the room.? The voice of the consumer carries so much weight because they are (at least in the consumer?s mind) equally invested in a product or service thanks to their purchasing power and brand loyalty.
It?s the answer to this question that made the entire conference worth it. If brands don?t listen to consumer input, whether or not they participate in the conversation, they will lose half ownership of their brand. For example, brands who?ve decided not to participate in social media are finding that people will create fake profiles and accounts and post/tweet on their behalf. By choosing not to be engaged, they?re losing hold of their voice.
In short, the value of an authentic voice outweighs any money spent if you don?t find out who is influencing and who is engaging. Even consumers who aren?t engaging (social voyeurs) are still influenced by their circle of friends and family.
With all of this in mind, here are five ways I believe you should approach branding as a shared-ownership model:
1. Learn who is talking about you. Think you know your target audience? Maybe you do. But what if you don?t? The first step in this shared-ownership model is to know who your co-owners are. Brands make all kinds of assumptions about who they?re marketing to, but they?re not always right. Confirm your suspicions by engaging with your social networks. If you don?t have any, start building.
2.?Know where are they are. This goes along with #1. Details?you need to know details. Where is your audience? What do they want from you? What are their passions? What kind of message resonates with them?or in other words, how do you speak their language? Knowing the details allows you to create more targeted messaging and hone in on what matters to them. So much can be learned about your audience by simply knowing where they are.
3.?Listen to what they are saying. A funny thing happens when you listen to your audience. Your passion for your brand is fueled by the passion of your customers. You begin to understand who you are building something with and how you can deliver more value. And all of you together create a new sense of co-ownership. It?s community building at its finest. But only if you listen.
4. Discover when they?re saying it. This is really a part of the listening process?here?s where you can learn what seems to spark conversation on your social media channels. What gets people talking? Pay attention to the events and circumstances surrounding the chatter, and you?ll discover how and when to best engage with your audience.
Determine how will you respond. Nothing to respond to right now? Perfect. That?s the best time to develop a plan. Too many brands respond off the cuff, without thinking it through and creating a social media engagement strategy. I?m not saying don?t be real and authentic. Quite the contrary. Be human, but be trustworthy, professional, personable and maybe even funny (gasp). Humor goes a long way in disarming unhappy consumers, and if it fits your brand, it?s a great quality to add to your response strategy. But like I said?work on that now so when it?s time to respond, you?re not caught off guard.
KEY TAKEAWAY: When it comes to brand marketing, don?t give your consumers more power and ownership than they deserve?BUT don?t fail to recognize their influence and impact, either. Your audience has a number of channels in which to create their own messaging about your brand. If you don?t participate in the conversation, you?re missing out on crucial opportunities. Shake hands with your co-owners.
ScienceDaily (Oct. 25, 2012) ? Astronomers using NASA's Hubble Space Telescope have obtained a remarkable new view of a whopper of an elliptical galaxy that may have been puffed up by the actions of one or more black holes in its core.
Spanning a little more than one million light-years, the galaxy is about 10 times the diameter of our Milky Way galaxy. The bloated galaxy is a member of an unusual class of galaxies with a diffuse core filled with a fog of starlight where there would normally be a concentrated peak of light around a central black hole. Viewing the core is like seeing a city with no downtown, just houses sprinkled across a vast landscape.
Astronomers used Hubble's Advanced Camera for Surveys and Wide Field Camera 3 to measure the amount of starlight across the galaxy, dubbed A2261-BCG. The Hubble observations revealed that the galaxy's puffy core, measuring about 10,000 light-years, is the largest yet seen.
A galaxy's core size typically is correlated to the dimensions of its host galaxy, but in this case, the central region is much larger than astronomers would expect for the galaxy's size. In fact, the bloated core is more than three times larger than the center of other very luminous galaxies. Located three billion light-years away, the galaxy is the most massive and brightest galaxy in the Abell 2261 cluster.
Astronomers have proposed two possibilities for the puffy core. One scenario is that a pair of merging black holes gravitationally stirred up and scattered the stars. Another idea is that the merging black holes were ejected from the core. Left without an anchor, the stars began spreading out even more, creating the puffy-looking core.
Previous Hubble observations have revealed that supermassive black holes, weighing millions or billions times more than the Sun, reside at the centers of nearly all galaxies and may play a role in shaping those central regions.
"Expecting to find a black hole in every galaxy is sort of like expecting to find a pit inside a peach," explained astronomer Tod Lauer of the National Optical Astronomy Observatory in Tucson, Ariz., a co-author of the Hubble study. "With this Hubble observation, we cut into the biggest peach and we can't find the pit. We don't know for sure that the black hole is not there, but Hubble shows that there's no concentration of stars in the core."
Team leader Marc Postman of the Space Telescope Science Institute in Baltimore, Md., said the galaxy stood out in the Hubble image. "When I first saw the image of this galaxy, I knew right away it was unusual," Postman explained. "The core was very diffuse and very large. The challenge was then to make sense of all the data, given what we knew from previous Hubble observations, and come up with a plausible explanation for the intriguing nature of this particular galaxy."
The paper describing the results appeared in the Sept. 10 issue of The Astrophysical Journal. The astronomers expected to see a slight cusp of light in the galaxy's center, marking the location of the black hole and attendant stars. Instead, the starlight's intensity remained fairly even across the galaxy.
One possibility for the puffy core may be due to two central black holes orbiting each other. These black holes collectively could have been as massive as several billion suns. Though one of the black holes would be native to the galaxy, a second black hole could have been added from a smaller galaxy that was gobbled up by the massive elliptical.
In this scenario, stars circling in the giant galaxy's center came close to the twin black holes. The stars were then given a gravitational boot out of the core. Each gravitational slingshot robbed the black holes of momentum, moving the pair ever closer together, until finally they merged, forming one supermassive black hole that still resides in the galaxy's center.
Another related possibility is that the black-hole merger created gravity waves, which are ripples in the fabric of space. According to the theory of general relativity, a pair of merging black holes produce ripples of gravity that radiate away. If the black holes are of unequal mass, then some of the energy may radiate more strongly in one direction, producing the equivalent of a rocket thrust. The imbalance of forces would have ejected the merged black hole from the center at speeds of millions of miles an hour, resulting in the rarity of a galaxy without a central black hole. "The black hole is the anchor for the stars," Lauer explained. "If you take it out, all of a sudden you have a lot less mass. The stars don't get held down very well and they expand out, enlarging the core even more."
The team admits that the ejected black-hole scenario may sound far-fetched, "but that's what makes observing the universe so intriguing -- sometimes you find the unexpected," said Postman.
Added Lauer: "This is a system that's interesting enough that it pushes against a lot of questions. We have thought an awful lot about what black holes do. But we haven't been able to test our theories. This is an interesting place where a lot of the ideas we've had can come together and can be tested, fairly exotic ideas about how black holes may interact with each other dynamically and how they would affect the surrounding stellar population."
The team is now conducting follow-up observations with the Very Large Array radio telescope (VLA) in New Mexico. The astronomers expect material falling onto a black hole to emit radio waves, among other types of radiation. They will compare the VLA data with the Hubble images to more precisely pin down the location of the black hole, if it indeed exists.
The Abell 2261 cluster is part of a multi-wavelength survey, led by Postman, called the Cluster Lensing And Supernova survey with Hubble (CLASH). The survey probes the distribution of dark matter in 25 massive galaxy clusters.
The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency. NASA's Goddard Space Flight Center in Greenbelt, Md., manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Md., conducts Hubble science operations. STScI is operated by the Association of Universities for Research in Astronomy, Inc., in Washington.
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The above story is reprinted from materials provided by Space Telescope Science Institute (STScI).
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Update: Philly.com combines sources. The article in question has a Daily News header. I?ve changed my headline to reflect that.
Hmm. This is also despicable -?Alleged killer ?liked? ?Find Autumn Pasquale? Facebook page- they were likely monitoring progress of the search and investigation. As for Philly.com naming them, I am wondering if their rationale is, they named themselves through social media?
Justin Robinson knew exactly where Pasquale was ? because he allegedly had lured her to his home on East Clayton Avenue on Saturday afternoon and then beat and strangled the seventh-grader with the help of his brother, Dante Robinson, 17? before they stuffed her into a blue recycling container..
SEARCHERS returned from the forests and fields Sunday night, their voices hoarse from calling Autumn?s name, and those who loved her the most huddled close together in Clayton, holding fast to hope.
Meanwhile, at 8:16 p.m., a 15-year-old Clayton boy logged onto Facebook and, along with nearly 17,000 other people across the country, clicked ?Like? on the FIND AUTUMN PASQUALE page.
But authorities say Justin Robinson knew exactly where Pasquale was ? because he allegedly had lured her to his home on East Clayton Avenue on Saturday afternoon and then beat and strangled the seventh-grader with the help of his brother, Dante Robinson, 17, before they stuffed her into a blue recycling container.
Tuesday?s revelation that Pasquale?s alleged murderers were Clayton residents ? teens who lived just a few blocks from Pasquale ? made it all the more heartbreaking for residents. Thousands of fliers were handed out, plastered in windows and on telephone poles, even out by the fall foliage along Wilson Lake. On Monday night, just hours before a searcher found Pasquale inside the container by the curb next-door to the Robinson home, hundreds gathered for a candlelight vigil, softly singing ?Amazing Grace? as Autumn?s father, Anthony, sobbed.
Apple launched a number of new hardware products today, including a new iPad, smaller iPad Mini, a 13" Retina MacBook Pro, and a few new desktop Macs. Here's everything Apple released today.
The new 4th generation iPad is pretty much what you'd expect: it has a better graphics, a better processor, longer battery life (10 hours claimed), and even faster Wi-Fi. It also has a Lightning port for charging, as well its new Lightning-to-USB and Lightning-to-HDMI cables. They also released the long-awaited iPad Mini, which has a slightly different form factor (thinner and less wide than the regular iPad) and a 7.9" screen. It also has the same battery life and same screen resolution as the regular iPad, so all your apps should work without any updates (which is actually really nice).
Apple also introduced a new 13" MacBook Pro with a Retina display, a new Mac Mini with USB 3.0, and a new super-thin iMac. Both the Mac Mini and iMac have the added option of a "Fusion" drive, which is essentially a hybrid SSD that gives you SSD performance with hard drive-level capacities. They also released a new version of iBooks with continuous scrolling, which you can grab in the App Store.
You can check out all the devices in more detail on Apple's web site now. The new iPads are available for preorder on Friday for Wi-Fi models and two weeks later for LTE models. The 21.5 inch iMac is coming in November, and the 27 inch will be available in December. The Mac Minis and MacBook Pro should be available in the store today.
ScienceDaily (Oct. 24, 2012) ? A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology.
"This is the first confirmed report that this protein, called Elf5, is a tumor suppressor in breast cancer," explains Satrajit Sinha, PhD, associate professor of biochemistry in the UB School of Medicine and Biomedical Sciences and a corresponding author on the paper with Yibin Kang, PhD, in the Department of Molecular Biology at Princeton University.
The researchers say the findings provide new avenues to pursue in treating and diagnosing breast cancer and possibly cancers of other organs as well. The paper includes findings from both animal and human breast cancer models.
Under normal circumstances, Elf5 is a transcription factor that controls the genes that allow for milk production.
But when the researchers used knockout mice developed at UB, in whom Elf5 was removed, they found more than just an inability to produce milk. They found that epithelial cells in the mammary glands also became more mesenchymal, that is, more like stem cells, an early harbinger of cancer, Sinha says.
"We found that when Elf5 levels are low or absent, epithelial cells become more like stem cells, morphing into mesenchymal cells, changing their shape and appearance and migrating elsewhere in the body," says Sinha. "This is how cancer spreads."
The UB-Princeton collaboration began when lead author Rumela Chakrabarti, PhD, originally a postdoctoral researcher in Sinha's laboratory at UB, took a position in the laboratory of Yibin Kang, PhD, Warner-Lambert/Parke-Davis Professor of Molecular Biology at Princeton, whose research focus is breast cancer metastasis. This allowed Chakrabarti to harness the expertise of the two laboratories to generate such a breakthrough finding.
"Elf5 keeps normal breast cells in their current shape and restricts their movement," says Chakrabarti. She found that the protein accomplishes this by suppressing the epithelial-mesenchymal transition by directly repressing transcription of Snail2, a master regulator of mammary stem cells known to trigger the EMT.
"Elf5 keeps Snail2 repressed, but once Elf5 is lost, then there is nothing to repress Snail 2," she explains.
The paper notes that Elf5 loss is frequently detected early in the disease at the breast hyperplasia stage, when the number of cells increases. In experiments conducted by the Princeton scientists, the researchers also found that little or no Elf5 in human breast cancer samples correlated with increased morbidity.
"It seems that loss of Elf5 is an initial event in the disease, so it could also be an important diagnostic tool," Sinha notes, which is a current focus of the UB and Princeton team.
"We want to know, how early does the loss of Elf5 occur? Could we use loss of Elf5 as a reliable diagnostic tool?" he asks.
The finding reveals the complex pathways through which breast cancers develop, he says, while also providing new avenues to pursue for diagnostics and treatments.
"Our research shows that the EMT-Snail 2 pathway is a valuable one to target for early breast cancer intervention," says Sinha, "possibly by designing something to recapture the repressive effect of Elf5 or a drug that could mimic Elf5 activity. And this is just one molecule, part of a big network. That's why we are now creating a detailed map of this molecule and its associated partners in order to give us a better idea of what to look for."
Other UB co-authors on the paper are Rose-Anne Romano, PhD, research assistant professor in biochemistry, and Kirsten Smalley, research technician. Other coauthors are: Julie Hwang, Mario Andres Blanco, Martin Lukacisin and Yong Wei from Princeton; Song Liu of Roswell Park Cancer Institute; Qifeng Yang and Bruce F. Haffty of the Department of Radiation Oncology in the University of Medicine and Dentistry of New Jersey and the Cancer Institute of New Jersey; and Toni Ibrahim, Laura Mercatali and Dino Amadori of the Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori in Italy.
The research was supported by the National Institutes of Health, the Department of Defense, Komen for the Cure, the Brewster Foundation and the Champalimaud Foundation.
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Rumela Chakrabarti, Julie Hwang, Mario Andres Blanco, Yong Wei, Martin Luka?i?in, Rose-Anne Romano, Kirsten Smalley, Song Liu, Qifeng Yang, Toni Ibrahim, Laura Mercatali, Dino Amadori, Bruce G. Haffty, Satrajit Sinha, Yibin Kang. Elf5 inhibits the epithelial?mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nature Cell Biology, 2012; DOI: 10.1038/ncb2607
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
"Toxicology is always a limitation because you''re giving these preventive treatments to otherwise healthy people, so the threshold for toxicity is very low," said lead researcher David McCormick, Ph.D., senior vice president and director at the ITT Research Institute in Chicago. "Dual inhibitors may provide superior chemopreventive activity, as well as a better toxicologic profile."
Using a well-studied rat model, McCormick and colleagues induced oral cancer and tested different licofelone doses, including 37.5 mg/kg per day and 75 mg/kg per day, as well as 75 mg/kg per day after a six-week delay following the induction of cancer.
In a control group, 75 percent of rats developed squamous cell carcinoma, the predominant oral cancer in humans, most often at the base of the tongue. They also developed a variety of precancerous lesions.
Forty-three percent of rats assigned to high-dose licofelone and 55 percent assigned to the low-dose administration developed cancer. Those assigned to the compound after a six-week delay had a 34 percent incidence of oral cancer. McCormick noted that delayed administration can compromise the anticancer activity in some compounds. The fact that licofelone retained its anticancer action bodes well for its preventive potential, as patients may have already developed precancerous lesions before they seek treatment.
Researchers also observed a decreased incidence of the most advanced (highly invasive) cancers with licofelone: a 17 percent incidence with both doses compared with 54 percent in controls.
Although cancer incidence was reduced in the treated rats, the incidence of precursor lesions increased, again confirming licofelone''s ability to suppress the development of oral cancer, according to the researchers.
When it comes to designing a house, most people tend to focus more on the interior since it is the part where the members of the family will spend the most of their time. However, this does not mean that the outside part of the home should not be given importance. If you want to have a nice looking house, you would need to take care of the outdoor part too. It is what people will see when they visit your house. It would be odd if the outside part would not complement the beauty of what is inside. There are actually a lot of things you can do to make your outdoors look good. It would be excellent to have a professional designer create the structure and design for you but it is also great to come up with your own design in order to ensure that what will be done is according to your preferences and that all your needs will be taken care of.
Choose the Right Type of Paint - One of the simplest things you can do to make the outside part of your home look better is to have a good wall paint color. Choose something that would complement the overall look of your house may it be vintage, elegant, or modern. There is a wide variety of paint types and colors you can choose in the market. Though it is a very simple thing to do, it could have a big and positive effect.
Add Outdoor Furniture - It is common to have a lot of furniture indoors but there are also some outdoor furniture made available by different furniture shops today. Among them are the wicker outdoor sofas, outdoor coffee tables, and garden furniture. These types of furniture do not only enhance the outdoor design of your beloved property but it also provides functionality.
Outdoor Garden - This is one of the best ways to make your home outdoor designs look excellent. Having a garden would also enable you to help the environment. Hire a landscape artist or you can do it yourself. Start with something small and gradually work your way into having different plants, flowers, and even a tree depending on how much space you have outdoors.
Have a Deck and Patio - This is ideal if you have a big budget. A deck and patio are like an extension of your home which helps you achieve a certain outdoor design that you want. Much like having great outdoor furniture, a deck and patio would also add more functionality to your home apart from making it look better. Different patio designs are available out there and the best way to look for one is to ask an architect or a professional house designer.
These are just among the different ways to enhance the outdoor design of your house. In order to get the design that you want, you really do not have to spend much as long as you are resourceful and creative.
Frank Mitchell 768 Joel Klaas 767 Dave Klaas 743 Matt Langolf 740 Leo Anthony 739
Men?s High Game
Frank Mitchell 300 Joel Klaas 298 Frank Mowinski 279 Lew Gunn 279 Chad Jeroue 279
ST. CLAIR RIVER LANES
Women?s High Series
Kristen Herbert 684 Jaclyn Meldrum 637 Sue Pope 556 Cindy Herbert 512 Sharon Eckelbarger 502
Women?s High Game
Kristen Herbert 248 Jaclyn Meldrum 229 Cindy Herbert 212 Melissa Simons 201 Erica Cole 200
Men?s High Series
Jeff Meldrum 758 Henry Sullivan 726 Dirt Smith 705 Kevin Maas 673 Jim Gallaher 653
Men?s High Game
Jeff Meldrum 288 Dirt Smith 266 Wayne Leppek 258 Henry Sullivan 258 Kevin Maas 258
?League Highs
YOUTH LEAGUES BOWL O DROME
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Bumper (2-4): Madison Zimmerman 134; Kassidy Kavanagh 84; Mackenzie Zimmerman 83; Dylan Barnes 77; Clara Bellman 55; Lauren Bellman 39 Other: Kenny Herbert 696(267)(258); Tyler Fields 683(246); Devin Yelencich 618(226); Matthew Tetreau 579(232); Nicholas Snyder 523; Katie Hodgins 445(179); T.J. Klein 441(158); Tyler Elliott 433(181); Lindsay Klein 323; Amanda Levey 293; Emily MacPherson 279
PORT HURON LANES
Bumper (2-4): Matiaus Everhart 70; Ali Wise 74 Bantams (5-8): Xavier Lashbrook 236; Myles Guyette 90; Marissa Feil 199(88) Prep (9-11): Chase Colvard 425(149); Sydney Sepsey 379(143) Juniors (12-14): Nick Hedrick 480(178); Jessica Badley 363; Cady Morgan 126 Majors (15-21): Matt Wassom 642(255); Aly Irvine 479(205)
BLUE WATER BOWL Blue Water Mixers
Brenda Arnold 509; Julie Fetterly 498; Becky Van Hoesen 204; Steve Baker 670(247); Jeff Van Hoesen 616(213); Rich Scott 614; Dale Camphausen 214
Bucks & Does
Lee Ann Ganhs 569(231); Dwayne Rich 614(226); Jackie Karl 509(181); Mike Schindler 681(279); Jose Ganhs 621(234); Matt Campbell 563(207); Jim Halifax 556(197)
Dan Wilkinson Memorial
Jeff Morrison 716(278); Kevin Renno 691(243); Paul Collins 655(235); Ray Kowalski 687(236); Ray Randall 608(242); Alicia Schroeder 527(215); Joddy Swoffer 604(239); Jamie Yeager 558
Don McIvor Memorial
Paul Lewandowski 702(255); Rich Scott 651(236); Dale Camphausen 658(247); Jose Ganhs 687(246); Brad Ashton 675(256); Michael Ganhs 658(236); Jim Stoutmeyer 655(234); Doug Ultsch654(267); Gary Goddard 646(236); Chuck Ouellette, Jr. 683(244)
Friday Night Wanna Bees
Henry Sullivan 731(258); Greg Urben 663; Chris Sills 247; Chad Jeroue 644; Rich Scott 629; Eric Wehner 241; Wayne Baker 237
Mixed Singles
Becky Van Hoesen 549(241); Regina Dye 180; Marty Nichols 623(235); Rick Sosa 601(257); Lonnie Nichols 2343; Jeff Dettloff 214
Mon PM Adult Bowling
Bev Cummings 533(184); Jerry Bailey 506(178); Tom Trisch 506(211); Pat Fiedler 205; Bob Murphy 511(201); Jean Delacy 476(189)
Mueller Retirees
Pat Kennedy 510(184); Juanita Peter 512(184); Bev Cummings 182; Vic Gregowski 670(238); Pat Fiedler 607(233); Vince Sudomir 236
Port Huron Hospital
Joddy Swoffer 563(209); Anita Hubbard 561(204); Krista Hosmer 516; Lynette Compton 493(196); Erica Johnson 202
Viking Three Man
Ron Zimmer 691(278); Tony Hebel 667(247); Steve Jakubowski 653(235); Emmett Williams 237; King Thomason III 635(217)
BOWL O DROME Beverage
Bob Nicolai 660(290); Jeff Schott 278; Anthony LaGruth 631(269); Don Roach 664(245); Carl Schott 642(226); John Collins 669(236)
Beverage
Jeff Schott 772(299); Russ Knowles 686; Carl Schott 676(256); Scott Nichols 278
BOD Sunday Men?s
Tom Buchheister 721(258); Russell Barnes 701(246); Nate Kelly 698(245); Brian Doan 688(259); Greg Urben 684(246); Gary Marinez 682(259); Gordon Harvey 268; Jeff Wright 674(267); Tim Osmer 652(247)
Friday Doubles
Trish Defrain 696(269); Charlie Collins 664(237)
Original Sunday Funtimers
Judy Tidwell 540(222); Connie Hines 491(171); Noon Almendarez 483(177); Pam Diaz 177; Jane Morris 177; Tom Morris 682(258); Jesse Diaz, Jr. 664(248); Chuck Middleton 624(253); Rob Kelley 588(225); Craig Seaman 580(205); Rick Sosa 213; Joel Scouten 540
Port Huron Hospital AM
Wally Armstead 600(264); Jerry Grzech 690(239); Judy Mattson 503; Vic Gregowski 667(245); Jerry Bailey 587(210); Gordon Harvey 590(203); Gary Smith 732(279); Nadine LaGruth 539; Michelle Carlson 578(235)
Saturday Night Live
Jeff Schott 692(268); Rick Barr 646; John Cuthbertson 634(254)
Saturday Nite Out
Joel Scouten 614(243); Jim Stoutmeyer 604; A.J. Foltz 599(234); Jon May 599
Zebraettes
Shawne Lindgren 475(180); Sherry Mitchell 497(199); Lori Schreiber 179; Cheryl Joslin 173; Karen Chafty-Morgan 176; Linda Brennan 485; Cindy Badley
COLONY BOWL
Paul Fleming 720(261); Mike Kollmorgan 610(279); Mo Ibrahim 662(279)
PORT HURON LANES Adult Activities-Mon AM
Jane Angels 489(172); Marilyn Roach 455(170); Maxine Brown 47)(157); Ray Davis 577(225); Ron Messer 573(213); Bob Hall 560; Gary Milutin 213
Cowboys & Indians
Frank Mowinski 731(279)(268); Joel Klaas 767(298); Matt Langolf 731(268); Ray LaVere 724(267); Lew Gunn 716(279); Chad Jeroue 279; Richie Barnes 278; Crystal Cramer 615(238)
Friday Morning Industrial
Steve Jakubowski 703; Mike Schindler 730; Dom Cocco 709
Friday AM Seniors
Robyn Rossow 468(173); Jean Delacy 415; Barb Davis 414(149); Eleanor Sweeney 152; Robert Hall 659(255); Paul Fleckenstein 556 (235); Elmer Gamble 526(202)
Friday PM Seniors
Gerry Sedich 494(180); Elmer Gamble 665(245); Lysle Smith 725(255); Ron Dunlap 634(258); Mike Mullins 258
Inter City Ladies
Kristie Lashbrook 661(241); Michelle Jones 584(209); Sandy Drouillard 567(214); Ann Nichols 559(204); Amy Roach 201
Masters
Kevin Kavanagh 708(248); Tim Jackson 703(246); Jerry Hendrick 701(256); Jeff Krauss 690(245); Bruce Arnett 633(248); Don Hayes 623(246)
People of Faith
Aleiha Schmidt 616(209); Hayley Cox 471(196); Linda Crane 471; Sue Shovan 185; Don Thiede 686(243); James Jones 673; David Cox 657(246); Jim Atkins 244
PHL Early Four Man
Dave Klaas 743(269); Matt Langolf 740(256); Leo Anthony 739(266); Chuck Osentoski 712(244); Tom Schef 276; Brian Hayes 268; Doug Westbrook 267
Cindy Badley 502(189); Ashley Smith 477; Deb Turck 455; Corrie Churchill 174; Frank Mitchell 768(300); Scott Badley 735(257); Bob Pihaylic 678(268); Matt Pawlak 247; Jeremy Daggett 246
Tuesday AM Adult
Robyn Rossow 447(164); Marvel Holbrook 422(171); Rella Kilbourn 424(166); John Szczygiel 226; Max Frizzle 541(219)
Tuesday Early Ladies
Marie Belkiewicz 503(185); Sue Zuege 492(182); Maxine Brown 491(183)
Tuesday Mixed
Greg Allen 684(247); Matt Harvey 630(225); Lee Van Beek 602(244); Mike Colgan 567(257); Yolanda Reyes 505(194); Angie Allen 487(178); Robyn Wilson 432(157)
Wednesday Night Ladies
Melissa Rood 516(202); Jackie Karl 509; Cheryl Howe 532(219); Virginia Norton 522; Melissa Basic 538; Brenda Provost 542(224); Pat Kennedy 521; Noel Frost 524(200); Christie Moses 501; Stacy Grant 508(212); Sharon Soyko 631(257) Cec Simmons 509; Donna Paulus 507
?ST. CLAIR RIVER LANES Blue Water Mens
Henry Sullivan 726(258); Kevin Maas 673(258); Ed Martin 670(244); Dirt Smith 666(266); Bill McCoy 256
Ladies City League
Kristen Herbert 684(248); Cindy Herbert 512(212); Melissa Simons 201; Erica Cole 200; Mary Jane Young 504(182)
Monday Big 12
Jeff Meldrum 758(288); Jack Fletcher 650(257); Wayne Leppek 258; Dick Lumley 245; John Patterson 626(245); Rob Roberts 635(233)
River Queens
Sue Pope 556(192); Sharon Eckelbarger 502(196); Barb Galos 499(180); Leslie Heileman 466; Helen Gilbert 178
River Rats
Dirt Smith 705(258); Jim Gallaher 653(234); Jaclyn Meldrum 637(229)
NOTE: Bowling scores submitted to Blue Water Sports Network by Scott Wassom
This afternoon, mere hours before Raw kicks off in her home state of New Jersey, Raw General Manager AJ Lee posted the following on her official Twitter account:
@WWEAJLee: Been called to an emergency meeting with the WWE Board of Directors at #WWE Global HQ. #Confused #RAW
Earlier this month, the WWE Board of Directors put the eccentric authority figure on probation for slapping Paul Heyman. It is unknown at this time, however, whether AJ?s meeting with board members today in Stamford, Conn., is in any way related to her job performance.
AJ Lee?s confusion on the nature of this meeting is no doubt shared by the entire WWE Universe. Perhaps some answers will come to light tonight on Raw, live at 8/7 CT on USA Network.
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Yesterday, 06:27 AM
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#1 (permalink)
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Join Date: Nov 2006
Location: northern Virginia
Concierge Level: 6
Posts: 12,504
Escaping Election Chaos
Escaping Election Chaos ?a PTR for 31 October ? 3 November at WDW and 3 ? 10 November aboard the Fantasy.
It?s been a few years (we won?t discuss how many) since I attempted a trip report of any kind. I don?t know why I decided to start again, but this little three-day at WDW seems to be tailor made for getting my feet wet. Since we are just a few days from leaving?I better get busy! If I do well, perhaps I can do one on our long trip in May! Anyway, hands and feet must remain in the PTR at all times, stow all loose items and dispense with any liquid beverages?it could get bumpy out here.
Our cast: NanaTink?.54, Wife, Mom, Mema, family Disney planner. Busy planning trips since 2001. I work as an analyst for the Federal government in downtown DC at the Department of Justice.
Sulley?also 54, Husband, Dad, Papa, Disney enabler. Secret Disney lover, but if asked, it?s all for moi. He works at the Pentagon as a Public Affairs officer. Retired from the Navy in 1998 after 22 years, it took a lot of convincing on my part to get him to cruise.
Our first trip to Disney together was our very first vacation that wasn?t to visit family or connected to a move to a new duty station. Our youngest child had graduated from high school the year before, our oldest in the Navy himself.
I don?t remember who came up with the idea of going to Disney the first time, but I want to say the original idea belonged to Sulley, that he saw an advertisement for Shades of Green and thought it was perfect. As it turned out, SoG was undergoing renovation at the time, so they booked us into POR, Alligator, Bayou, and as they say, the rest was history! Or as I have been known to say, you have nobody to blame but yourself!
Since that first trip, we?ve made an additional 15 trips to the World, traveled to Disneyland 3 times and taken 9 cruises. In addition, we joined the Disney Vacation Club. And remember, this is ALL.MY.FAULT!
That?s us in my signature picture, it?s one of my favorites, taken on the Dream in June last year, which, coincidently this plan had its germination. As always, DCL had its onboard booking offers and we decided that since we both work in DC, and having been through the ?drama? of elections, both having political appointees as bosses, we did not want to be around during the election, either way it goes. Plus, we were excited to sail on the Fantasy as well, so the 3 November cruise jumped out as the perfect one. I booked it.
?Now wait,? you are thinking??this isn?t the cruise trip report area!? Fear not, there is a Disney stay attached?I just wanted to give you the beginning point.
Fast forward to Ocotber and you will find Sulley and I working on planning our January trip to WDW with our youngest son and his family. We were talking about leave plans for the upcoming year, and Sulley said, ?you know, I love taking the kids and the grandkids, but sometimes I just miss wandering around with just you and not having to plan around other people. When can we go just for us?? (Remember how Disney trips are ALL.FOR.ME? )
Up next: Time in the World Together
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Last edited by NanaTink; Yesterday at 06:29 AM..
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Yesterday, 06:59 AM
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#2 (permalink)
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Join Date: Nov 2006
Location: northern Virginia
Concierge Level: 6
Posts: 12,504
This Time is Our Time
When we travel for a cruise, we usually take Friday off, and travel down at our leisure and stay at the Hyatt MCO. It?s easy and we are right there for the bus to the port first thing in the morning! No concerns about flight delays. I looked at our point situation and realized we had plenty to add a few days at Disney before the cruise. We could fly down, take the DME to WDW and spend a few days wandering around! Sold, but still have to wait a few days for our 11 month window. I could still plan though!
Now, I know that October 31 is Halloween, and the Magic Kingdom will definitely have MNSSHP that night, and knowing they usually have a party a couple days afterwards, I asked Sulley if he was interested in going to the party again. He declined, saying, I just want to stroll around, do a few rides, take photos, nothing fast-paced as our last few trips have been. I agree, so low key is the plan. I?m reading everything coming out about the Fantasyland expansion and trying to figure out what will, won?t or might be open when we go?hmmmm.
Finally, our 11-month DVC window arrives and I hop online and book a Saratoga Springs one bedroom, arriving on October 31st, checking out November 3. Now many people will wonder why do we waste our points on a one-bedroom for only 3 nights.
There are a few reasons. I often have problems sleeping and get up and wander around. I don?t want to disturb Sulley with my nocturnal wanderings, so a one bedroom allows me to get up and go into another room to read if I want and not worry about keeping him awake. It also has the advantage of having a washer and dryer in the room, allowing me to do our laundry just before the cruise so I do not have to pack EXTRA clothes for the trip. Plus, I have the points, so why not?
I task Sulley with finding our airfare as he is a United Premier Exec frequent flyer which is helpful as our baggage is free and he is complimentary upgraded to Economy Plus, a god-send with his long legs! (Due to the budget crisis, his government travel was curtailed this year, so we will lose this perk next year )
We discussed our park plans, knowing our time is limited. I voice my desire to go to MK our arrival day of 31 October and see what the new Fantasyland has to offer, knowing that the park will close at 7 for non-party attendees, this will allow for a nice dinner following and maybe a trip to DTD. Sulley agrees, and states he of course wants to ride ToT and RnRC, so day 2 looks like DHS, possibly some wandering of Epcot FWF. I point out our time in MK will be limited our first day and I would like to go back and ride some rides and just wander the park. Sulley agrees. So we have a basic plan, now it?s time to think about food. Where should we eat?
Up next; Dining plans?.You want WHAT?
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Last edited by NanaTink; Yesterday at 07:01 AM..
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Yesterday, 07:14 AM
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#3 (permalink)
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Join Date: Apr 2006
Location: Mystic, CT
Posts: 2,082
Great Start!!! Fantastic that just the two of you are spending time in my favorite bubble!!!
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Yesterday, 10:23 AM
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#4 (permalink)
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Join Date: Aug 2008
Location: Ballston Lake, NY
Concierge Level: 2
Posts: 30,300
Great start!!
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Yesterday, 10:39 AM
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#5 (permalink)
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Join Date: Mar 2007
Posts: 112
Sounds fun. DH and I just returned from a 3 night stay that was supposed to be just us leisurely visiting the world. Well, we get there and there is still so much we want to do that it turned commando!
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Yesterday, 10:51 AM
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#6 (permalink)
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Join Date: Nov 2006
Posts: 1,106
I love the Halloween decorations at WDW; such a great time of year to visit. Have fun!
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Yesterday, 11:59 AM
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#8 (permalink)
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Join Date: Apr 2006
Location: Boston, MA
Concierge Level: 6
Posts: 7,118
Glad you decided to do a report! I loved the intro and it sounds like it'll be a great trip. I understand booking the 1-bedroom. So nice to have the extra space, laundry and that nice, big bathroom and tub!
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Yesterday, 02:29 PM
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#9 (permalink)
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Join Date: May 2004
Location: northern california
Posts: 9,315
Have Fun.
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Tammy
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Yesterday, 10:23 PM
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#11 (permalink)
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Join Date: Sep 2006
Location: Cleveland, Ohio, USA
Posts: 1,913
Great Start.. I have loved the rest of your TR's so I look forward to this one.
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Yesterday, 10:31 PM
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#13 (permalink)
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Join Date: Oct 2004
Location: new york
Posts: 7,729
great start
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Heather - "I'm Tinkerbell's biggest fan!"
WDW - August 1997 Off Property WDW - January 2005 AKL WDW - May 2006 Pop Century WDW- november-dec 2007 pop century WDW- dec/jan 2009/2010 pop century
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Public release date: 26-Oct-2012
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Apple launched a number of new hardware products today, including a new iPad, smaller iPad Mini, a 13" Retina MacBook Pro, and a few new desktop Macs. Here's everything Apple released today. 
Yesterday, 06:27 AM
He works at the Pentagon as a Public Affairs officer. Retired from the Navy in 1998 after 22 years, it took a lot of convincing on my part to get him to cruise. 
Or as I have been known to say, you have nobody to blame but yourself! 
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